Lafutidine vs cimetidine to decrease gastric fluid acidity and volume in children.

نویسندگان

  • Katsuya Mikawa
  • Kahoru Nishina
  • Takanobu Uesugi
  • Makoto Shiga
  • Hidefumi Obara
چکیده

To the Editor: We recently conducted a telephone survey of pediatric anesthesia departments in 11 Canadian university centres. Department chiefs (or designates) were asked to identify current anesthesia practice and concerns for pediatric magnetic resonance imaging (MRI). In all 11 centres, care was provided by pediatric anesthesiologists, with ten centres having MRI compatible machines available. All centres routinely used capnography and pulse oximetry. Eight centres routinely used non-invasive blood pressure monitoring. Five centres routinely used electrocardiogram (ECG) monitoring, and two centres had no MRI compatible ECG available. In seven centres the anesthesiologists were located in the control room during scanning. Staff were more likely to remain in the scanning room if a slave monitor was unavailable in the control room. Six centres predominantly used a propofol total iv anesthesia technique (TIVA), with the other five centres using a volatile technique more frequently or exclusively. Centres predominantly using TIVA were less likely to instrument the airway (Table). Propofol induction and maintenance dose estimates ranged from 2 to 6 mg·kg–1 (mean 3.7) and 100 to 250 μg·kg–1·min–1 (mean 165) respectively, with one centre using boluses as required rather than an infusion. Three centres routinely using TIVA had no MRI compatible infusion pump available; instead using a remote pump with a hydraulic interface, or a manual method calculating drops per minute. Propofol sedation techniques have been well described previously, although often with lower doses of propofol than we found in this survey. Centres not routinely using TIVA had concerns about maintaining and monitoring the airway if nasal prongs or a face mask were used. Annual caseload estimates ranged from 20 to 1,400 children. Many centres noted increasing demand from radiology departments for anesthesia services, with one centre commenting that anesthesia out of the operating room currently accounts for greater than 30% of the department workload. Most centres felt that seven to eight years was the age at which children more reliably tolerated scanning without anesthesia. The mean daily caseload for centres predominantly using TIVA was 9.2 (5–12) vs 7.2 (5–10) for other centres, possibly due to shorter induction and emergence periods as the airway is instrumented less often. We conclude that anesthesia for MRI accounts for a significant workload for pediatric anesthesiologists. Some centres remain concerned about the safety of TIVA using nasal prongs or face mask despite the suggestion it may decrease anesthesia time.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Afferent signalling from the acid-challenged rat stomach is inhibited and gastric acid elimination is enhanced by lafutidine

BACKGROUND Lafutidine is a histamine H2 receptor antagonist, the gastroprotective effect of which is related to its antisecretory activity and its ability to activate a sensory neuron-dependent mechanism of defence. The present study investigated whether intragastric administration of lafutidine (10 and 30 mg/kg) modifies vagal afferent signalling, mucosal injury, intragastric acidity and gastr...

متن کامل

Comparison of verapamil and cimetidine for their effects on volume and acidity of Carbachol induced gastric secretion in fasting rabbits.

BACKGROUND Peptic ulcer is a common ailment for which over production of gastric acid is the main cause. This study was undertaken to find out the effects of Calcium channel blocker Verapamil and Cimetidine on volume and acidity of Carbacol induced gastric section, free and total acidity of carbachol induced gastric secretion and their effects were also compared. METHODS Thirty rabbits of loc...

متن کامل

Protective effect of lafutidine, a novel H2-receptor antagonist, on reflux esophagitis in rats through capsaicin-sensitive afferent neurons.

We examined the effect of lafutidine, a novel histamine H(2)-receptor antagonist, on acid reflux esophagitis in rats in relation to capsaicin-sensitive afferent neurons. The esophagitis was induced in rats by ligating both the pylorus and forestomach for 4 h. Lafutidine (1 - 30 mg/kg) and cimetidine (100 mg/kg) were administered either intragastrically or intraduodenally, while capsaicin (1 - 3...

متن کامل

The effects of cimetidine and ranitidine with and without metoclopramide on gastric volume and pH in morbidly obese patients.

The efficacy of preanaesthetic intravenous cimetidine versus ranitidine with and without metoclopramide for acid aspiration prophylaxis was assessed in 60 morbidly obese patients in a double-blind manner. Group 1 patients received cimetidine 300 mg + saline. Group 2 patients received cimetidine 300 mg + metoclopramide 10 mg. Group 3 patients received ranitidine 100 mg + saline. Group 4 patients...

متن کامل

Effect of cimetidine on 24-hour intragastric acidity in normal subjects.

The effect of H2-receptor blockade on intragastric acidity was studied in nine normal males. The pH of their gastric contents was measured at hourly daytime and two hourly nighttime intervals for 48 hours. The subjects ate identical meals, drank identical volumes of fluid, and smoked the same number of cigarettes during the two study days. Their physical activity was unrestricted in a ward envi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Canadian journal of anaesthesia = Journal canadien d'anesthesie

دوره 50 4  شماره 

صفحات  -

تاریخ انتشار 2003